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![]() ![]() Ages of HapMap and disease-associated alleles were also estimated. In addition, allele frequency distributions of different disease classes were assessed. The set of all common disease-associated alleles found in genome-wide association studies prior to January 2010 was analyzed and compared with HapMap and theoretical null expectations. Characteristics of disease-associated alleles can be used to increase the yield of future studies. derived states of disease-associated alleles differ from the rest of the genome. An open question is whether the allele frequency distributions and ancestral vs. Genome-wide association studies give insight into the genetic basis of common diseases.
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